Similarly, it was recently demonstrated that a subset of CD24low FACsorted mouse neuroblasts express undetectable to low levels of EGFr [3], and that rat neuroblasts express EGFr [42].
For instance, mouse neuroblasts either coming from p53−/− mice or treated with p53 antisense oligonucleotides displayed accelerated neuronal differentiation (Ferreira and Kosik, 1996).
Mouse neuroblast cells were seeded and cultured on the PDL coated and uncoated neural MEAs with different tip-coatings such as platinum, molybdenum, gold, sputtered iridium oxide, and carbon nanotubes.
Down-regulation of Erk1/2 in NSC/NPCs and neuroblasts during aging may result in a decrease in overall Erk1/2 activity, leading to a decline in NSC/NPC numbers and consequently reduced production of new neurons.
Thus, EZH2 is expressed in SVZ astrocytes and neuroblasts during the period of postnatal human neurogenesis.
grh-GAL4 drives expression of UAS-linked genes in a subset of neuroblasts during reactivation.
Thus, dILPs, expressed by glial cells, are ideally positioned to activate the dInR pathway in neuroblasts during reactivation.
These results strongly suggest that pre-GEPCOT cells give rise to GEPCOTs, NICs, and neuroblasts during SVZ regeneration.
During Drosophila development, glial cells provide a niche that sustains the proliferation of neural stem cells (neuroblasts) during starvation.
In order to label and manipulate neuroblasts during the transition from quiescence to proliferation (reactivation), we generated a GAL4 line using a neuroblast-specific grainyhead enhancer (Prokop et al., 1998; Uv et al., 1997) (grh-GAL4).
