Sentence examples for motor neuron morphology from inspiring English sources

It manifest as abnormal spinal motor neuron morphology and muscle denervation leading to muscle atrophy and progressive paralysis [21].

Alternatively, the DD motor neuron morphology may be unstable in adults due to defective differentiation of the axon during the earlier outgrowth phase.

An important aspect of understanding the function of Wnt2 is to determine where at the synapse it functions to regulate presynaptic motor neuron morphology and localization of proteins.

Choline acetyltransferase (ChAT) labeling of motor neuron cell bodies in the ventral horn of the lumbar spinal cord in 6 and 24 month old Cra1/+ and +/+ mice demonstrates no observable difference in motor neuron morphology or ChAT expression in Cra1/+ mice (Figure 2A).

In Drosophila models of AD-HSP, larvae lacking Spastin exhibit abnormal motor neuron morphology and function, and most die as pupae.

Though several recent studies indicate that SMN influences motor neuron axonal morphology [19], [20], it remains unclear whether SMN has a specific neuromuscular junction (NMJ) function, and whether the functional requirement for SMN activity is increased at the NMJ than elsewhere in the organism.

That two primary motor neurons can develop normally in the presence of a third with pathfinding errors is consistent with published reports showing that the axon of a primary motor neuron adopts its cell-specific morphology independently of the other two primary motor neurons in the same hemisegment (Eisen et al., 1989; Liu et al., 1990; Pike and Eisen, 1990).

Moreover, the finding that downregulation of the zebrafish orthologue of C9orf72 leads to both altered morphology of motor neuron axons and locomotor deficits, and that these features are reversed upon overexpression of wild-type human C9orf72, further support the notion that C9orf72 loss of function is detrimental [ 14].

Morpholino-induced loss of heparanase 2 caused embryonic skeletal muscle paralysis, and morphant motor neurons had aberrant morphology including less linear paths and less compactly-bundled axons than normal.

Because of the significant effects that expression of human APP and BACE had on the morphology of the presynaptic motor neuron, we next determined whether the expression of human APP and BACE affected molecular aspects of motor neuron development.

(A ) Ubiquitous (Tubulin-Gal4 ) or ring gland (RG, Feb36-Gal4 ) expressiof of Marf rescue bouton morphology in Marf mutants, while motor neuron (D42-Gal4 ) or muscle (Mef-Gal4 ) Marf expression did not.