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The reasons for this motor neuron selectivity, however, are still unclear.
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Therefore, further studies on molecular mechanisms underlying the selectivity of motor neuron death in distal HMN will be critical to understanding the disease.
Thus, an ideal mouse model of SMA should faithfully recapitulate the cellular levels of SMN protein seen in patients in order to preserve the relative selectivity for motor neuron degeneration.
The selectivity of adhesive interactions has been shown to drive sorting at the cellular level, for example, cadherin-mediated motor neuron segregation (Patel et al, 2006) and Dscam isoform-coded dendritic self-avoidance (Meijers et al, 2007; Sawaya et al, 2008).
Human endogenous retrovirus-K contributes to motor neuron disease.
"You could make neurons from induced pluripotent stem cells taken from patients with Parkinson's or motor neuron disease.
Diane Pretty, 42, suffers from motor neuron disease and is paralyzed from the neck down.
MN, motor neuron.
Survival motor neuron.
Lower motor neuron.
Mutant PHP tau: altered motor neuron development.
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