In the current study, we found that the intestine was the most vulnerable splanchnic tissue during the dissociation between macrocirculation and microcirculation by conducting a multiple organ model, which may be the major difference in the current study compared to other experimental models.
If our findings reflect the consequences of the mitochondrial theory of aging, then brain is the most vulnerable post-mitotic tissue of those examined.
The extent of NHE6 expression did not, however, coincide with those areas that seemed most vulnerable to develop tissue pathology such as the amygdala and CA3 and CA4 regions of the hippocampus.
It is unclear why brain should be the tissue most vulnerable to these age related losses, and it is not at all obvious why mitobiogenesis is so impaired during aging.
When oxygen is breathed at high partial pressures, a hyperoxic condition will rapidly spread, with the most vascularised tissues being most vulnerable.
The high-energy demand tissues are most vulnerable to this process and, in part, are responsible for the clinical features of Leigh syndrome.
