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The existence of reciprocal interactions between the immune and central nervous systems (CNS) makes the brain be one of the most vulnerable organs during sepsis.
These become apparent the earliest in the most vulnerable organs, which are, among others, retina and kidney.
The most vulnerable organs to CO-induced hypoxia are the heart and the brain because of their high metabolic rate [ 7].
Hence it could be accepted that testis is one of the most vulnerable organs in the body to external stimuli such as heat, MF, or chemical agents.
This is facilitated by the fact that the metabolic activity of the fetal liver is not yet well developed so leading to a higher half-life of nicotine with the ability to interfere in the development of especially the most vulnerable organs, including the lung [ 35].
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The lung is the most vulnerable organ to injury because it contains many blood vessels.
Mesenteric ischemia-reperfusion represents an important cause of extrapulmonary ARDS, as gut mucosal perfusion deficits appear to be instrumental in the propagation of multiple organ failure, of which the most vulnerable organ is the lung [ 4].
Because of the rich blood supply to the alveoli, and because alcohol is absorbed and distributed in an unaltered state (unbound to proteins or complexed with other transport systems) it could be argued that the lung is the most vulnerable organ following immediate alcohol absorption.
Remember that your skin is your body's largest and most vulnerable organ.
The lung is regarded as the most vulnerable remote organ injured after intestinal I/R.
The gut and/or fat body may represent the organs most vulnerable to aging, so that DAF-16/dFOXO directly prevents the otherwise lethal age-related pathologies in these organs.
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