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Exact(5)
The most significant putative targets were listed in Table S1.
To assess the utility of our method, we focused on the 32 known SNPs between B6 and D2 in probes of the 100 most significant putative cis eQTLs.
Among the 100 most significant putative cis eQTLs there was an excess of 74 cisN2 eQTLs (enrichment significant at P<<0.001; chi-square test).
To study the potential influence of SNPs in probe sets on cis eQTL identification, we investigated the 100 most significant putative cis eQTLs in detail.
Three metrics were helpful to assess the utility of the statistical method in a set of 100 most significant putative cis eQTLs in a mouse study: Is the statistical method flagging as many genes with cisB6 eQTL as the observed excess of cisB6 over cisD2 eQTLs?
Similar(52)
Six significant missense mutations in this genomic region were considered as the most important putative variants.
This analysis indicates that both WT (CD19) and Raji human B-cells are among the most significant tissues thus validating the putative enhancer regions identified in our analysis and as described in mouse lymphocytes (Li et al., 2012 ).
The most significant correlation was found for a putative Kunitz-type invertase inhibitor (KT-InvInh).
Moreover, the most significant gene network based on the putative target genes is involved in neural system function and development.
The most significant was SO4405 (KatG-2), a putative heme-containing enzyme that catalyses the dismutation of hydrogen peroxide into water and oxygen, was highly up-regulated in the mutant WG3 and exhibited more than a 5-fold difference in transcription (Table 3).
MEME identified 45 putative LexA-binding sites with an overall E-value of 1.4e-026 for its most significant predicted motif, while BioProspector detected 39 putative LexA boxes in its most significant predicted motif (see Additional file 1 for details).
Related(20)
most significant potential
most significant imputed
most significant possible
most robust putative
most frequent putative
most encoding putative
most important putative
most relevant putative
most upregulated putative
most interesting putative
most pronounced putative
most conserved putative
most other putative
most feasible putative
most ancient putative
most likely putative
most probable putative
most common putative
most populous putative
most significant natural
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