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There is a statistically significant correlation between levels of Bid and survival, with the most responsive cell lines displaying lower levels of full-length Bid (Figure 8A).
At this dose of the combination treatment, there is an almost two-fold difference in viability between the most responsive cell line (SK-MEL-2) and the least responsive (MeWo) (P<0.0001; Supplementary Figure S2).
For example, tetra-methylthiuram disulfide is 250-fold more potent in SH-SY5Y than the next most responsive cell type, and methyl mercuric (II) chloride is 50-fold more potent in NIH 3T3 than the next most responsive cell type.
Gelsemium s. 2c was checked in SH-SY5Y and IMR-32 cells and the most responsive cell line was chosen for testing also higher dilutions/dynamizations.
First imagine a decoder which considers the animal as localized within the grid fields of the most responsive cell in each module (Coultrip et al., 1992; Maass, 2000).
Two chondrosarcoma cell lines showed complete resistance (NDCS-1 and L2975), whereas in the two most responsive cell lines (SW1353 and L3252) a maximum reduction in cell viability of ∼40% was achieved.
Similar(53)
The efficiency of receptor coupling with adenylate cyclase also differs among immune cells, with natural killer cells and monocytes being the most responsive cells.
In contrast the SMA-expressing myofibroblasts present in the perivascular compartment and in the blood vessel wall contained a number of proliferative cells positive for the proliferation marker Ki67, showing that myofibroblasts are the most responsive cells to the proproliferative signaling present in the DC tissue.
When we analyzed the amplitude distribution of the single-cell responses we observed that from 1 pM to 10 µM p, p′-DDE most responsive cells showed an increase in fluorescence intensity of up to 20%, but at higher doses the shape of the distribution was completely different, with 'enhanced' response amplitudes ranging between 20 and 100% and occasional responses of up to 200% (Fig. 2D).
Natural Killer (NK) cells, the most responsive immune cells to acute exercise, show a striking exercise-induced increase, whereas their cell count drops to below half the normal level after exercise [ 8, 9].
We then selected the most responsive RMS cell line, RMS-13, to see whether BA-induced apoptosis indeed requires caspase activation.
Related(15)
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Justyna Jupowicz-Kozak
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