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Bothersomeness of leg symptoms was the most responsive outcome associated with the largest magnitude of effect size.
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Even clinical outcomes with changes that are highly predictive of progression to AD or MCI may not be the most responsive outcomes longitudinally in populations that we are able to define prospectively.
Toe proprioception was the most responsive NPx outcome and was associated with 6 of 16 OP pesticides.
It is important to note that the clinical outcome most responsive to treatment is not necessarily the one with the largest effect on treatment satisfaction or preference (6 ).
Important questions remain regarding the health outcomes most responsive to exposure effects, possible differential effects of specific chemicals, and the actual pathophysiological process responsible for observed impairments.
To assess coping in terms of cognitive and behavioral strategies of pain tolerance and pain management we used the following five scales of the Coping Strategies Questionnaire (CSQ): increasing activity, praying and hoping, catastrophizing, ability to control pain, and ability to decrease pain because these were found to be the most responsive coping scales in our previous outcome study [ 22- 24].
Objectives: To identify the most responsive method of measuring gait speed, to estimate the responsiveness of other outcome measures, and to determine whether gait speed predicts discharge destination in acute stroke.
The purpose of this review was to determine the frequency of positive behavioral outcomes in AD clinical trials and clinical reports, to determine the symptoms most responsive to antidementia agents, and to explore factors that correlate with negative outcomes in clinical trials of antidementia agents with regard to behavioral measures.
The choice of DAS28 as main outcome measure was based on some evidences that it resulted as the most responsive and discriminative instrument [ 16] as well as it was considered as an outcome measure for the peripheral joint involvement in PsA patients [ 17].
Using the criterion of treatment of known efficacy may show which instrument is the most responsive in relation to existing interventions, but the most common application of patient-reported outcome measures is in the evaluation of new interventions including the randomised comparison with existing interventions which will produce more marginal gains in terms of clinical effectiveness.
It was used as the primary outcome measure for this study as it has been found to be the most responsive of the SDQ subscales to counselling [ 14].
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