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Unfortunately, at present, neither the identity nor the selection path for the most appropriate cell population for optimal graft integration are known.
There are multiple cell types available and one of the challenges will be to find the most appropriate cell type for cardiac regeneration.
A key conclusion is the need to design the most appropriate cell counting method, including control/measurement assurance strategies, for a specific counting purposes.
Various weight fractions (0.5, 1, 2, 3 and 3.5 wt%) of PEO were used, of which 2 wt% PEO in the cell-laden strut resulted in the most appropriate cell release and enhanced biological activities (cell proliferation and calcium deposition), compared to nonporous cell-laden struts.
Identification of the most appropriate cell sources for different potential applications, development of appropriate clinical grade methodologies and large scale well controlled clinical trials will be essential to assess safety and value of cell based therapies, which have been generating much hope, but are by and large not yet close to becoming standard clinical practice.
Among the main issues, the optimal timing for therapy and the most appropriate cell delivery route might be of particular importance in order to maximize cell transplantation efficiency.
Similar(45)
This ability to suppress or enhance autophagy may allow p53 to provide the most appropriate cell-survival strategy during nutrient starvation (Scherz-Shouval et al., 2010); in mouse embryonic fibroblasts with low basal autophagy, the effect of p53 is to increase autophagy during starvation.
Metazoans have evolved ways to engage only the most appropriate cells for long-term tissue development and homeostasis.
Validated SNPs that fit into multiple cells were represented in the left-most appropriate cell.
The recent discovery in the adult mammalian myocardium of a small cell population with the phenotype, behavior, and regenerative potential of cardiac stem and progenitor cells has proposed these cells as the most appropriate for cell therapy.
Interval of 12 h appeared to be the most appropriate for cell kinetic analysis of Jurkat cells with the proposed method, because there were considerable proportions of cells both in the Sld compartment and in the Slu compartment.
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