Sentence examples for most potent activator from inspiring English sources

The synthetic androgen MB was the most potent activator giving 14-fold induction of luciferase activity.

Simply, the machinery that is activated during apoptosis (caspase activation) also acts through the BCL10/MALT1/CARMA pathway to activate NF κB, which is the most potent activator of HIV transcription, via the HIV LTR.

In certain cell types, K-Ras is the most potent activator of Raf-1 [ 40, 41], whereas H-Ras most efficiently activates PI3K [ 40].

For instance, while all ErbB receptors activate the MAPK pathway via Shc and/or Grb2, ErbB3 is the most potent activator of PI3K signalling due to its multiple binding sites for the p85 regulatory subunit of PI3K [ 7, 8].

The most potent activator that emerged from his screens was resveratrol, a natural substance found in red wine, though in amounts probably too low to be significant for health.

In contrast, it is testosterone, rather than its metabolites, that is the most potent activator of male sexual behavior in green anole lizards.

Our results demonstrate that DDT and dichlorodiphenyldichloroethane (DDD) were the most potent activators of AP-1 activity; 2,2-bis p-chlorophenyl) acetic acid failed to activate.

Our data demonstrated that Clerodendrum polysaccharide sub-fraction CSP-AU1, which was one of the most potent activators of cytokine production, activated PBMCs and monocyte/macrophages via TLR4 and signaling cascades involving Akt2/3, GSK-3α/β, p38β, p38δ, p38γ, p70S6K1, RSK2, mTOR, and AP-1/NK-κB.

Since activated BRAF is one of the most potent activators of MAP kinase signaling and BRAFV600E mutation itself has been described in a subset of human prostate cancers[25], this iBRAF* model represents a potentially useful in vivo system in which to address the role of MAP kinase activation in prostate cancer genesis and progression.

In particular, long chain, polyunsaturated LPA species (like 22 4 LPA) have been shown to be the most potent activators of certain biological processes, such as platelet activation [ 35].

Endotoxin is a lipopolysaccharide in the membrane of gram negative bacilli, and is known to be one of the most potent activators of the inflammatory response in humans.