By this approach we identified the N-benzylated beta-proline derivative of tocainide (To10) as the most potent use-dependent blocker of Nav1.4 so far.
The intrinsic activity of the most potent clinically used triptan, subcutaneous sumatriptan 6 mg, is thus higher than the maximal effect of the intravenously used CGRP antagonist, olcagepant 2.5 mg.
l-3,4-Dihydroxyphenylalanine (l-DOPA) is the most potent drug used for treatment of Parkinsonism.
30.5% of the entire sample had a negative score on the pain management index, a comparison of the most potent analgesic used by a patient relative to their worst pain.
These two drugs are the most potent drugs used in TB treatment.
On the basis of the analytical TLC, these fractions were combined into 5 new fractions (SF. 1 to SF. 5) and screened to find the most potent fraction using only acetic acid induced writhing.
To construct the index, we determined which of four levels of analgesic drug therapy was the most potent one used: 0, no analgesic drug; 1, a non-opioid (e.g., a non-steroidal anti-inflammatory drug); 2, a weak opioid (e.g., codeine or tramadol); and 3, a strong opioid (e.g., morphine, fentanyl, buprenorphine, oxycodone and so on).
Also, a serious limitation for vaccines are the adjuvants available for use in humans; the most potent known adjuvants used in animal models cause side-effects, and so new adjuvants that are both effective and safe for use in humans are needed.
This influence was exerted through many aspects of sympathetic magic, one of the most potent being the use of language.
Cruz added that the military commanders he has consulted insist that "the most potent tool to use against ISIS is overwhelming airpower".
