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Within the Th1 immune response, the most potent trigger for macrophage-induced ROS production is interferon-gamma (IFN-γ) [40].
The surgical damage to the jaw that occurs after extraction, especially the damage to the alveolar bone with open bone wounds, seems to be the most potent trigger for MRONJ.
The addition of IL6 together with IL23 and IL1α was the most potent trigger of all.
For cough evaluation, bradykinin was the most potent trigger (p < 0.01).
The most potent trigger of a debate in the public sphere many individuals would engage in is a mobilising controversy.
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This effect may be highly relevant, since (i) continued T cell activation also represents a central element in psoriasis [30], and (ii) Wnt5a-mediated T cell activation can be elicited by lithium which is one of the most potent clinical triggers of psoriasis flares [31].
In our study, LPS and TNF-α were the two most potent agonists in triggering the release of the three cytokines.
Possibly uremia is the most potent factor which triggers immune activation, and further changes induced by the different types of renal replacement therapy are too subtle to be apparent.
Stressful life events are among the most potent factors that can trigger the development of psychiatric disorders such as depression and anxiety disorders [ 1- 3].
Stressful life events such as bereavement, or a disabling medical event are amongst the most potent factors that can trigger depressive symptoms (Cole and Dendukuri, 2003) and are both more likely to occur in old age.
In liver fibrogenesis TGF-β is the most potent profibrogenic signaling factor triggering expression, accumulation and deposition of collagen [ 30].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com