The most potent acid-inhibitory drugs are the proton pump inhibitors such as omeprazole, lansoprazole, and rabeprazole that block the final pathway of acid secretion and are effective for 15 to 17 hours.
As the most potent acid-suppression drugs, PPIs have substantially replaced H2 receptor antagonists for the treatment of acid-related gastroesophageal diseases.
Lithocholic acid appears to be the most potent bile acid agonist for the receptor (41).
We identified the most potent fatty acid among those contained in the fatty acid mixture in producing changes in the elevated plus maze and tested three different concentrations of this fatty acid in the same test.
Furthermore, the 2-amino/acetamido-indane-5-sulfonic acids prepared during this work also showed interesting CA inhibitory properties, with inhibition constants in the range of 43 89 nM against the two isozymes, being among the most potent sulfonic acid CA inhibitors reported so far.
Of the three major Ca2+ mobilizing messengers described, the most potent, nicotinic acid adenine dinucleotide phosphate (NAADP) is the least well understood in terms of its molecular targets [ 1].
Leucine is one of the most potent amino acids in stimulating MTOR signaling.
FXR can be activated by both primary and secondary conjugated bile acids, but chenodeoxycholic acid appears to be the most potent natural bile acid ligand (16, 17).
Scavenging affect of various fractions with ascorbic acid showed that LPME (IC50; 63.4 ± 3.65 μg/ml) had (P < 0.01) highest hydroxyl radical scavenging affect and was most potent than ascorbic acid (IC50 76.3 ± 2.15 μg/ml) respectively.
This activity was superior to that of the most potent antibacterial anacardic acid isolated from the cashew Anacardium occidentale (Anacardiaceae), apple and nut, that is, the 6-[8′(Z),11′(Z),14′-pentadecatrienyl]salicylic acid.
