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A model-based design of experiments strategy was applied for selecting the most informative experiments to achieve a precise estimation of the kinetic model parameters.
Often, in fact, an important task is the selection of the most informative experiments.
This problem is intimately linked to identifying the most informative experiments for accomplishing such tasks.
The final s.g.i., which is proportional to the Euclidean distance, is then based on the most informative experiments.
The most informative experiments are those where specific perturbations radically alter a normal morphology, and the resulting configurations must be describable by any useful ontology.
By choosing only the most informative experiments from the vast S. cerevisiae literature, we were able to survey a large phenotypic space at high accuracy with a modest amount of experimentation.
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It will be challenging, but ultimately most informative, to devise experiments to address this last question.
In other words, 20 SVs are enough to separate intra-pathway co-expressions, and the set of arrays corresponding to these SVs is considered most informative among 2364 experiments.
In both the network topology and parameter inference challenges, participants were asked to develop and/or apply optimization methods, including the selection of the most informative in silico experiments, to accurately estimate parameters and predict outcomes of perturbations from a model of a gene regulatory network.
This counting method was the most informative for this experiment and did not require gene length normalization.
One objective of experiment design is to devise experiments yielding the most informative data for use in the estimation of the model parameters.
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