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Our experiments show that human subjects frequently perform the most informative tests, leading to a decline of false positives as expected from the simulations.
Results from computer simulations indicate that for the tasks analyzed in this study, the fraction of false among the positive findings declines over several rounds of testing if the most informative tests are performed.
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Such insights allow geotechnical practitioners to inspect the quality of information from different testing procedures (including test results and transformation models adopted to interpret them) and to identify the most informative test procedure.
The most informative test is selected.
Knowing the error rates is essential for determining the most informative test.
The increase is less pronounced than in the simulations, because human subjects did not always choose the most informative test.
This decrease is less pronounced than in the simulations because the most informative test was not always selected (15% for SIM-1 vs. 19% for pooled data from EXP-1S, EXP-1G and EXP-1S*; p = 0.01).
The most informative test to measure lung function was selected for each age group (Beydon et al. 2007; Bisgaard and Klug 1995; Dab and Alexander 1976).
While testing large numbers of compounds may be impractical, computational approaches can exploit existing data to determine the most informative substrates to test next, thereby more thoroughly exploring an enzyme's versatility.
With a robust strand-inheritance analysis tool and accurate SCE calling, BAIT is able to interrogate Strand-seq data to follow template-strand segregation patterns, and is currently the most informative technique for testing such patterns [ 29- 32].
Suppose that we would like to optimally expand a training dataset 𝒟, such that we can make most informative predictions about a test set 𝒟test.
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