Therefore, they mediate various biological processes such as neuronal morphogenesis, tumor invasion, and bone formation.
They mediate diverse biological processes, including neuronal morphogenesis, tumor invasion, and bone formation, and act in a coordinated manner to modulate cellular functions.
This model mimics the steps sequential bone morphogenesis and has permitted the isolation of bone morphogens, such as bone morphogenetic proteins (BMPs).
The cell-cell adhesion molecule cadherin-11 is important in embryogenesis and bone morphogenesis, invasion of cancer cells, lymphangiogenesis, homing of cancer cells to bone, and rheumatoid arthritis.
It plays a crucial role in the morphogenesis of tendon, ligament and bone.
Activins and inhibins are members of the transforming growth factor beta super-family that play roles in skeletal development and bone morphogenesis [ 23].
We identified the previously reported Bapx1 binding motif T(G/A AGTG [ 28], enriched in about 40% of the Bapx1 binding sites in the genome specifically near genes controlling cartilage and bone morphogenesis.
Bone morphogenetic proteins were originally identified as cytokines inducing ectopic chondro-osteogenesis and have a role in skeletal and joint morphogenesis, bone remodelling and fracture repair (Urist, 1965; Chen et al, 2004).
While a cadherin switch in epithelial cells could trigger metastasis, a similar switch in osteoblasts could profoundly disrupt bone morphogenesis and promote osteosarcoma formation by affecting the cell-to-cell interactions that drive osteogenic differentiation.
BSP is produced by osteoblasts, osteoclasts, and osteocytes during bone morphogenesis and homeostasis.
