More importantly, after treatment with DHA, A549GR cells showed more potent induction in Bax activation, loss of mitochondrial membrane potential (ΔΨm), caspase activation and apoptosis than A549 cells.
These observations could lead to a more informed selection and design of other HDACi with a more refined targeting profile, and prioritization of latency reversing agents of other classes to be used in combination with SAHA to achieve more potent induction of HIV expression.
This reduction of T cell activity may result in a more potent induction of neutralizing antibody responses, clearing the viral infection.
As demonstrated for several antigens and with healthy donors' as well as melanoma patients' cells, the pDC line led to a more potent induction of tumor-specific T cells endowed with better functional capacities compared to conventional mDCs.
Similarly, stimulation of TIL from melanoma patients with GEN cells led to a more potent induction of tumor-specific T cells than semi-allogeneic mDCs in respect to both tetramer+ T cell percentage (Figures 8A and 8B) and fold increase in absolute number of specific T cells (Figure 8C).
Inhibition of HDAC9 leads to enhanced suppressive Tregs' function and proliferation pointing toward a more potent induction of anti-inflammatory T-regs by panobinostat than vorinostat.
