More intensive and prolonged induction strategies have been published, claiming an increased remission rate (Kushner et al, 1994).
In contrast, while the activation of BMM upon infection by HN878 was suboptimal at earlier time points, the response was more prolonged and included the induction of genes involved in host cell lipid and small molecule metabolism.
More prolonged or acute tension wood induction has been shown to produce high-glucan, low-lignin phenotypes [ 18, 25, 26].
We found that EGF (20 ng/ml) induced many of the same genes as LPA (5 μM), although LPA stimulation often led to a higher level of induction and/or more prolonged kinetics.
Consistent with their hypothesis, the authors found that although both groups of adolescents exhibited significantly elevated cortisol response to the TSST relative to their respective baseline levels, depressed participants showed significantly higher and more prolonged cortisol secretion following psychosocial stress induction when compared with control subjects.
In contrast, SI probably provides a more representative sample of proximal airways, although with prolonged induction the distal parts can also be sampled as evident from increased numbers of macrophages from the alveolar compartment (Gershman et al. 1999; Holz et al. 1998).
In contrast, determination of time-dependent hAR activation by TBECH indicates slower receptor activation and prolonged induction times, suggesting that these compounds are more stable in this cell line.
Significant benefits were obtained when moderate hypothermia was maintained for at least 12 24 hours, but it has been suggested that more prolonged treatment, up to 72 hours [ 42], may be necessary if the interval before induction of hypothermia is prolonged [ 43].
6 The standard therapeutic strategies in older patients tend to induce deeper and more prolonged myelosuppression, which is likely a major determinant of early treatment-related morbidity and mortality seen in the course of induction in these patients.
That could result in a much deeper, more prolonged downturn.
