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Importantly, this work demonstrates the more efficient induction efficiency of human ES cells differentiation by the nanoparticle drug formulation.
MMS, ENU and MMC induced both gene mutations and structural chromosome aberrations in KN63 cells, with more efficient induction of the latter.
The NPR1 expression profile was similar to that of EDS1, except that it had a much more efficient induction at 3 hai (Figure 5O).
A more efficient induction of innate and adaptive immune responses potentially via the application of existing vaccines via different routes could also be beneficial in cases where standard vaccination regimens have been unsuccessful, so far (e.g., cancer and HIV).
It is noteworthy that the attenuated BCG, inducer of weak infiltration and inflammation, or virulent and highly persistent M. tuberculosis, both induce recruitment/expansion of Treg, while one should expect that virulent mycobacteria would elicit more efficient induction of Treg to avoid tissue injury.
Together with the observed enhancement of TRAIL activity, this may favor a more efficient induction of apoptosis in tumor cells.
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Intraosseous transplantation of donor BMC under αβTCR/CsA protocol was 75% more efficient in induction of donor-specific chimerism compared to intravenous transplantation.
These results indicated that ShhMSCs were more efficient in induction of mature and medium sized blood vessels as compared with EmpMSCs.
On Day 7, 1,25(OH)2D3, was equipotent to 20,23(OH)2D3 but was more efficient in induction of morphological differentiation than the other compounds tested (Fig. 4A; Table S3E).
Thus, we reasoned that we might observe more efficient iPSC induction if we ectopically expressed these miRNAs during reprogramming.
TGF-β inhibition also enables more efficient iPSC induction, as does omission of Sox2 and cMyc (Ichida et al, 2009; Maherali and Hochedlinger, 2009).
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