Considering that lin(bh23 ) animals show a similar but more severe VPC induction defect, we suspected that this could be another allele of Cbr-lin-39.
This study was concurrent chemoradiotherapy, and toxicities, such as mucositis, leukocytopenia and neutropenia, were thought to be more severe than induction chemotherapy, so that we reduced the initial dose level of docetaxel and 5-FU.
This study was concurrent chemoradiotherapy, and toxicities, such as mucositis, leukocytopenia, neutropenia, were thought to be more severe than induction chemotherapy; therefore, we reduced the initial dose level of docetaxel and 5-FU, and the initial dose level (level 1) was decided to be docetaxel 60 mg m−2 (day 1), cisplatin 70 mg m−2 (day 4) and 5-FU 600 mg m−2 days1 5days 1 5).
PGRN−/− mice exhibited more severe inflammation following induction of oxazolone (OXA).
Using these mice, we demonstrated that Tg mice developed more severe arthritis upon induction in the absence of IL-10 signaling.
Our data are supported by previous studies using more severe methods of OA induction in combination with OVX [ 13, 45].
In addition, the degree of miR alteration correlates with virus severity since a more severe virus produces a stronger P-miR164a induction.
This model, in its simpler formulation (LEM I), predicts a higher cell killing for higher densely ionizing (LET) radiation, correlating a higher spatial concentration of ionizations on a biological target, and then the induction of more severe damage to a higher probability to induce a lethal effect and than cell death.
In EAE, the animal model for MS, it has been considered an immune adjuvant responsible for a more severe course of disease and the induction of disease in animals not previously susceptible [39].
