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There are concerns that this virus may mutate or reassort with other existing influenza viruses to give rise to more readily transmittable or more pathogenic viruses.
Alternatively these mice could have died through the induction of a hyperimmune response (cytokine storm) which has been reported for more pathogenic viruses.
Virulence might also trade off with transmission such that more pathogenic viruses spread more slowly (2 ).
From the pandemic's start, there have been concerns the virus may mutate or reassort with contemporary influenza viruses and give rise to more pathogenic viruses.
Although apoptosis may be a protective rather than a pathogenetic mechanism because less pathogenic viruses induced more apoptosis than more pathogenic viruses [ 16, 19, 20], all of our patients were bitten by street rabies virus variant transmitted by rabid dogs.
Phylogenetic studies have shown regular extinction of strains of dengue viruses in single locations and emergence of new strains (16, 17 ), and it has been suggested that the appearance of more fit or more pathogenic viruses may occur as a result of immunologic selection during periods of intense transmission during outbreaks (18 ).
Similar(54)
Although the prior study clearly showed prior infection confers resistance to superinfection/viremia with a more pathogenic virus, the mechanisms of this protection remain unclear.
The robust and significant associations with a fitter protease, more circulating virus, higher immune-activation and CXCR4 co-receptor use suggest that CRF19_cpx may be a more pathogenic virus.
Because of the recent zoonotic transmissions of triple reassortant swine influenza (H3N2) viruses in the United States during 2010 (36 ), we also sought to determine whether reassortment had the potential to lead to a more pathogenic virus than previously circulating swine influenza strains.
Such a reassortant was responsible for several cases of influenza among humans in 2011 (15 ); these cases were mild, but other, more virulent pathogenic viruses could emerge.
A strong cytokine response along with induction of the TLR and RIG-I pathways ensure that the duck is able to survive or delay infection with the more pathogenic H5N1 virus.
Related(20)
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