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"The genetic sequences of these more recent viruses looked very much like the sequences of older viruses," Fukuda said.
Amidst the media's frenzied coverage of the Ebola disease and the more recent viruses including H1N1 and SARS, exists a part of history that is now little mentioned or perhaps forgotten--the Great Influenza of 1918.
Dk/HK/149/77 with a Gln226 exhibited dual specificity with preference for α2-3 sialosides, while the more recent viruses with Leu226, comprising two avian isolates and one human isolate (Dk/HK/Y280/97,Qa/HK/NT16/99 and Hu/HK/1073/99), exhibited broad preference for α2-6 sialthough (alimited limited binding to α2-3 sialosides was also evident for all three viruses with no clear pattern).
Sera raised against older strains react poorly to more recent viruses resulting in new strains having a selective advantage over previously established strains.
In contrast, the antigenic distances for the Yamagata viruses had no correlation with time or phylogenetic distance and showed greater levels of antigenic cross-reactivity between antisera raised to both earlier and more recent viruses.
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While she is struggling to return to full strength, her opponent, 18-year-old Madison Keys, has been dealing with a more recent virus this past weekend that has left her largely confined to her home.
Phylogenetic analysis revealed significant divergence between early LPAI H5N2 viruses (1994 - 1998) and more recent virus field isolates (2002 - 2008).
These results indicate that at the HA antigenic level, 2002 and 2005 LPAI viruses were more closely related to A/Ck/México/CPA-232/1994 than more recent virus isolates (2006 - 2008) (Table 2).
The USA/2006 P gene differs from the more recent 2002 viruses at codon 152 but is the same as all three 1988 isolates.
The corpse yielded DNA closely related to more recent variola virus specimens.
Moreover the close resemblance means it did not need to mix its genes with a human influenza virus to infect people, as did two more recent pandemic flu viruses.
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