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Whereas the TLR2 ligand bacterial lipopeptide preferentially induced the expression of MMP1 and MMP3, the TLR3 ligand poly (I C) was a more efficient inducer of MMP13 and MMP3 and also induced MMP1 to a lesser extent.

The above results suggest a potential involvement of the actin cytoskeleton in STATc activation and this possibility was tested using two drugs that disrupt the cytoskeleton: latrunculin A and cytochalasin A. Both induce STATc tyrosine phosphorylation, with cytochalasin A acting as the more efficient inducer (Fig. 2A).

At low concentrations (up to 10 µM) TETA is a more efficient inducer than Ni, which becomes a very efficient inducer at higher concentrations (50 µM).

Our impression from these studies is that amyloidogenic αS is a more efficient inducer of pathology than the non-amyloidogenic αS.

Of note, in both Colo205 and HCT15 cells, rhTRAIL was a more efficient inducer of apoptosis than either DR4 or DR5 agonistic antibodies.

The finding of bexarotene to be a more efficient inducer than RA for myogenesis in the ES cell system is novel and significant [ 46].

Similar(54)

Also, explorations of HDACi generated by Merck (MRK1, MRK4, MRK10 14) with varying degree of HDAC selectivity showed that inhibitors of class I HDACs were more efficient inducers of HIV-1 expression than inhibitors of class II HDACs in cell lines and resting CD4+ T cells from patients on cART.

Thus, factors that repressed both BMP and Activin signals, such as Noggin and Cerberus, were more efficient retinal-inducers than Follistatin, an Activin-biased antagonist.

Arsenite is a much lesser inducer of MT but a more effective inducer of HSPs, while nickel is a good inducer of MT but poor inducer of HSPs [ 119 ].

These results are, however, not only consistent with the carbon-dependent nature of the cellulolytic system in T. reesei, but also suggest that the sugars present in the CMM (sucrose) may be more efficient than lactose as an inducer for the main cellulolytic enzymes.

Although we could not determine the precise mechanism, we speculate that this change may be an indirect consequence of lignocellulase secretion induced by AP-3 comalfunctionnction, which could yield more efficient degradation of cellulose to produce biopolymer inducers to maintain lignocellulase gene expression.

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