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Alternately stated, when p53 is wild-type CPD lesions may be a more powerful inducer of apoptosis, however, once p53 becomes mutated (as is commonly observed for non-melanoma skin cancers) CPD lesions may act to induce cell cycle arrest.
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This assumption is based on the finding that miR-20a is a more powerful senescence inducer than si-LRF, although it is a milder inhibitor of LRF/inducer of p19ARF (Figure 2c) and that in LRF-null MEF additional senescence is induced (figure 3e).
Although further studies should be addressed, our findings support the conclusion that OMVs act as more powerful SIRS inducers than LPS alone, and that both vesicular LPS and other vesicular components including proteins should be crucial in the pathogenesis of sepsis-induced lethality.
The more powerful IFNγ inducers Con A and anti-CD3 stimulated levels of cytokine production that were less influenced by practicing Qigong, only Con A-induced IFNγ-SC at 3 weeks being significantly higher than before training (Fig. 4A).
4-ADBA was a slightly more potent inducer of primary DNA damage as compared to clenbuterol.
Co-protoporphyrin is a much more potent inducer of heme oxygenase in liver than is inorganic cobalt; and Sn-protoporphyrin inhibits heme oxygenase activity nearly completely, whereas inorganic tin is a powerful inducer of the renal enzyme.
Indeed, if this were the case, one might expect that ozone, a powerful inducer of pulmonary inflammation, would be able to cause even more substantial cardiovascular changes than PM, which has not been shown to date.
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