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It is interesting to note that BMP-2/6 is a more effective inducer of expression of differentiation markers than BMP-2 or BMP-6, even though it is a heterodimeric assembly of BMP-2 and BMP-6, and BMP-6 is not an active inducer of differentiation.
Thus, bexarotene is a much more effective inducer than RA to enhance the differentiation of ES cells into skeletal muscle lineage [ 46].
Arsenite is a much lesser inducer of MT but a more effective inducer of HSPs, while nickel is a good inducer of MT but poor inducer of HSPs [ 119 ].
Since we observed a large decrease in the level of plk4 transcripts in heterozygous MEFs upon UV exposure and since UV is a more effective inducer of both p53 activity and apoptosis than IR [ 42] we examined the levels of apoptosis after UV treatment.
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Therefore, this study may contribute to the fields of cancer therapy and cell death research by identifying DMC as a more effective paraptotic inducer than curcumin, while also clarifying the functional significance of proteasomal modulation and CHOP induction in paraptosis.
Several Cu chelators, developed for clinical applications [25] are now being tested, and some of them are more effective CYC6 inducers than TETA, while retaining reversibility by Cu.
IL-17 and IL-22 are potent inducers of psoriasin and a combination of them has been shown to be more effective in inducing psoriasin secretion in keratinocytes than the two cytokines separately [27].
The data suggest that di-GA is a potent inducer of apoptosis and significantly more effective than GA alone.
In contrast, T. reesei RUT-C30 was found to be more effective at secreting cellulolytic enzymes with purified cellulose as an inducer (data not published).
However, as an inducer of two 3-MC-inducible isozymes of P-450, HCB was clearly more effective in aromatic-hydrocarbon-responsive mice (C57Bl/6J) than in non-responsive mice (DBA/2J), suggesting that HCB may act through the Ah receptor.
However, as an inducer of resistance to PVX, SA was markedly more effective in these plants than in non-transgenic or Aox-transgenic plants, with virus accumulation decreased to barely detectable levels.
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