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Exact(6)
Overall, consensus mutations at more conserved positions were more likely to be stabilizing in our model, triosephosphate isomerase (TIM) from Saccharomyces cerevisiae.
One alternative hypothesis for explaining some of these observed trends is that earlier protein additions to the ribosomal machinery would have more conserved positions involved in specific RNA-protein interaction, while later additions would have more conserved positions involved in specific protein-protein interaction.
This decreases incrementally toward the more conserved positions of the OV-sorted alignment.
As expected, variable positions have higher dN/ dS values than more conserved positions.
The more conserved positions in the 3D profile are interior-facing L3, L5, L3', L5', L3" and L5" restricted to small hydrophobic residues and threonine and serine.
We searched the more conserved positions of the so-called -35 and -10 elements, i.e. the motifs TTG and TANNNT, separated by 19 to 21 bp [ 29, 30], N representing a non-defined nucleotide.
Similar(54)
Using SNP information in this small-size population, they found that genomic positions with low-DAF SNPs are more conserved than positions corresponding to high-DAF SNPs and rare SNPs with derived minor alleles are more likely to be located in functional genomic regions (Zhu et al. 2011).
Also, when the two ends of IESs are compared, positions 3, 4, and 5 are significantly more conserved than positions 6, 7, and 8 (supplementary table S3, Supplementary Material online).
In summary, we have shown that evolutionarily related genes have more conserved intron positions compared to merely similar sequences.
We conclude that orthologous genes tend to have more conserved intron positions compared to non-orthologous genes.
Consistent with the high bootstrap value for this clade the corresponding genes share one or more conserved intron positions in all except one case.
Related(20)
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more moderate positions
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more remote positions
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more flexed positions
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