Sentence examples for more active molecules from inspiring English sources

Contour maps obtained from the 3D-QSAR model are meaningful in designing more active molecules to act as direct inhibitors of thrombin.

The analysis of the biological data observed in the described series of compounds mays represents a platform for the design of more active molecules.

If the exploration of the chemical space is limited by the speed at which molecules can be scored, an optimist consensus of ECFP4 or UMOP2D fingerprints can outperform a consensus of scores in terms of finding more active molecules.

In the gut, phytoestrogens can be further metabolized to more active molecules, such as equol, O-desmethylangolensin (O-DMA), dihydrodaidzein, dihydrogenistein, enterolactone and enterodiol (Fig. 4) (Gaya et al., 2108; Axelson and Setchell 1981; Wang et al., 2005).

To seek for more active molecules, further investigation of this fungus has resulted in the isolation of two pregnene steroids (1 and 2) and three sesquiterpenes (3 5) (Fig. 1).

In this study we investigate the use of high level QM methods to study the interactions found within protein ligand complexes as improved understanding of these could help in the design of new, more active molecules.

In the intrinsic pathway, stimuli such as drugs, radiation, or hypoxia induce DNA injury, change mitochondrial permeability, and then discharge more active apoptotic molecules such as cytochrome C, which then combine with apoptotic protease activating factor-1 (Apaf-1) and procaspase-9 to form an apoptosome.

In summary, by comparing the data of in vitro inhibitory activities of the three series of A, B, and C, it can be seen that as A, B, and C molecule increases, the activity tends to decrease, suggesting that the smaller the side chain molecule of the R1 is, the more active the molecule is.

This enzyme is a sphingolipid Δ4-desaturase that converts dihydroceramide into ceramide, with the latter being a more active signaling molecule.

HMW adiponectin is postulated as the more biologically active molecule, binding avidly to its receptors, thus stimulating AMP activated protein kinase [ 18– 20].

The descriptors having higher positive score FS means there are more preferred in active molecules as comparison to inactive molecules.