Both the phase marker gene and the detailed analysis of deep sequencing data of 4th instar locusts showed that gregarious locusts are more active in pathways involved in detecting and processing of environmental information, while solitary locusts are more active in pathways associated with metabolism and biosynthesis.
The higher growth rates correspond to more active metabolic pathways available to cope with the NADH drain, and thus the metabolism tends to choose those pathways with higher efficiency in converting the metabolic resource originally for the biomass production to the current output.
And the brain network associated with emotional connection and empathy may become more active as pathways involved in memory and internal reflection become impaired.
Compared with control fibroblasts, non-induced RA synovial fibroblasts have more macroautophagy and are more resistant to proteasome inhibition, suggesting that they have more active lysosome/autophagy pathways enabling them to compensate for proteasome inhibition.
In the breast cancer cell line MCF-7, it was recently shown that TICs isolated by mammosphere formation assays have a more active DNA SSBR pathway demonstrated by increased levels of RAD51 foci and expression of the APE1 protein compared to total cells [ 70].
Overall, there is a strong indication that involvement of PNP-GDEPT correlates with a more active involvement of pathways involving downregulation of Bcl-2, survivin and drug resistance proteins, leading to a high apoptotic index as achieved in the synergies involving PNP-GDEPT.
We found that higher NKG2D ligand expression increased the sensitivity of sesamolin-treated Raji to NK cell lysis, resulting from a more active ERK signaling pathway.
All differences were statistically significant, suggesting that sphere-growing cells show increases in aggressiveness markers and possess a more active hedgehog signalling pathway.
We used EssOilDB to test this hypothesis and found that green parts of plants (that are likely to have a more active plastidial MEP pathway) do indeed show relatively greater amounts of released hemi, mono and diterpenes, as compared to sesquiterpenes.
These results also suggest that, compared with other fibroblasts, RA synovial fibroblasts have more active proteasomal and lysosomal pathways.
