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Here we explore an intriguing hypothesis that large non-coding RNA molecules might represent a molecular trafficking system that modulates chromatin modifying complexes to establish specific epigenetic landscapes.
This increased expression of fatty acid uptake molecules might represent a compensatory response to the higher levels of serum lipids in the HIGH group (Table 1).
Incidentally, the interplay between supporting and erasing energy fluxes, which is apparent in the case of photostable RNA-like molecules, might represent the physical essence of biological evolution (see [ 92, 394, 395] for related discussions).
While part of these molecules might represent degradation products of the TART transcripts, our data suggest that different transposon classes are differentially affected by mutations in the Cuff protein.
Although a functional role for PECAM-1 remains to be determined, the analogous increases in expression of adhesion molecules in both mouse and fly suggest that differential intercellular adhesion mediated by Ig domain-containing molecules might represent a more widely conserved characteristic of curved tissues throughout evolution.
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We then would like to propose that this configuration of FN4-A-linker-FN5-FN6 molecule might represent a stable "resting" state of the DCC receptor.
Based on the strong expression in HSPCs and the dynamic expression pattern of EpCAM during liver cell differentiation, this molecule might represent a central target in the field of hepatocellular differentiation and liver regeneration.
Because tumour cells from most ATLL patients express CCR4 (Ishida et al, 2003), we postulated that this molecule might represent a novel molecular target for immunotherapy and developed a chimeric anti-CCR4 monoclonal antibody (mAb), KM2760 (Niwa et al, 2004).
Thus, one may postulate that the subtle effect of these 'secondary' molecules might be heterologous seeding of Aβ, which could represent one of the trigger for more severe Aβ pathology during AD.
Some sites can be expected to provide monocultural collections of certain types of object (e.g. molecules) while others might represent the work created in a particular institution.
Alternatively, the expression of neurotoxic molecules might be induced.
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