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These biological pathways might represent a phenomenon occurring in muscle with highly divergent marbling phenotypes.
These molecular pathways might represent a new mechanism by which EGCG exerts anti-tumor effect through manipulating TAM and tumor microenvironment, as illustrated in Figure 5.
Thus, the stronger activity in S. kudriavzevii of the genes involved in one of the main amino acid pathways might represent this metabolic bottle-neck having been better surpassed in this species.
Antigenic peptides produced through proteasome-independent pathways might represent interesting targets in the context of immunotherapy, as some of those antigens might keep being expressed by tumors without being influenced by the surrounding environment.
In this context, effective reduction of tube formation and mitogenic activity of endothelial cells by ObR antagonist, especially in the combination with VEGFR2 inhibitor, suggest that targeting both leptin and VEGF pathways might represent a new therapeutic strategy to treat GBM.
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In this context, the CD28-PTEN pathway might represent a novel regulation mechanism of peripheral tolerance mediated by Treg.
In fact, the PI3K/Akt pathway might represent a promising therapeutic target [41], since significant progress has been made in developing small-molecule kinase inhibitors targeting the binding of pleckstrin homology (PH) domain of Akt to PIP3 or PIP2, which prevent Akt activation and membrane translocation [52], [53].
Modulation of this pathway might represent a potential target for treatment for septic and ARDS patients.
Therefore, this pathway might represent a promising novel target for therapeutic strategies in NASH.
This pathway might represent a novel and specific target for pharmacological strategies in patients with NASH.
This observation suggests that the Wnt pathway might represent a promising therapeutic target for degenerative neuromuscular diseases like OPMD.
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