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Other members of the superfamily methylate a variety of chemically diverse molecules, including various RNAs, proteins, lipids, small molecules, etc.
Matrix metalloproteinases (MMPs) form a large family of zinc-dependent metalloendopeptidases that degrade extracellular matrix (ECM) molecules, including various collagens, gelatine, elastin, fibronectin and aggrecan [ 1].
Neutrophils are essential cellular components of the innate immune system [ 10] and their accumulation and activation at the site of infection requires local induction of a panel of innate immune molecules, including various chemokines and cytokines [ 11].
Naturally occurring human mutations and molecular genetic studies have identified several instructive signaling molecules, including various transforming growth factor-β (TGF-β) [ 32], bone morphogenetic protein (BMP), growth and differentiation factor (GDF) [ 33] and Wnt [ 34] ligands.
The hemicellulose oligomers liberated into solution undergo continuing hydrolysis to form a variety of pentose monomers, which then undergo dehydration reactions to give furfural as a major product, which then further degrades to a variety of molecules, including various organic acids and condensation products [ 29].
A more highly purified biopharmaceutical grade of rhTF is also being developed at Ventria Bioscience for use in pharmaceutical applications such as being used as a potential conjugate carrier to a number of drug molecules, including various chemotherapy drugs for drug targeting and delivery.
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Indeed, we and others could recently show that disease associated mutations in phosphorylation sites or of critical residues constituting their recognition by cognate kinases are found in various signalling molecules, including several docking protein family members [ 57, 59, 60].
Investigators optimized the design of CARs to enhance receptor mediated T cell signaling and demonstrated that second and third generation CARs, including various costimulatory molecules, resulted in enhanced T-cell persistence and sustained antitumor activity in both in vitro and in vivo mouse models as well as clinical trials.
In the context of exon array analyses, we define the overall gene expression index as the total abundance of all molecules transcribed from a single gene, including various alternative splice forms, alternative 5' transcripts, alternative poly A transcripts, etc.
The so far functionally studied surface proteome of pancreatic beta cells is composed of a structurally diverse network of proteins that interacts with environmental molecules, including metabolites, ions, hormones, various peptides and proteins (Fig. 2).
Recognition of microbes relies on the sensing of microbe associated molecular patterns (MAMPs) by germline-encoded host pattern recognition molecules (PRMs), which include various families of leucine-rich repeat (LRR) bearing proteins in plants and animals.
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molecules including several
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molecules including numerous
compounds including various
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molecules including antimicrobial
molecules including simple
molecules evoking various
molecules including folded
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molecules including biological
molecules including large
molecules including many
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