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Three distinct molecular subgroups of ATRTs, associated with differences in demographics, tumor location, and type of SMARCB1 alterations, were identified.
Similarly, we identified distinct molecular subgroups of BRAF-mutant tumors, and multidimensional analyses highlighted a potential involvement of oncomiRs in less-differentiated subgroups.
The recently-defined four molecular subgroups of medulloblastoma have required updating of our understanding of in vitro models to include molecular classification and risk stratification features from clinical practice.
Molecular subgroups of medulloblastoma: the current consensus.
Consistently, genetic profiling of primary OD revealed that both genetic alterations are part of two distinct molecular subgroups of OD [32].
c-Met/nestin/IDH1-R132H c-Met/nestin/IDH1-R132H c-Met/nestin/IDH1-R132H c-Met/nestin/IDH1-R132H glioma.
Similar(5)
Chromosomal rearrangements of ALK and ROS1 genes in non-small cell lung carcinoma (NSCLC) define a molecular subgroup of lung adenocarcinoma (ADC) that is amenable to targeted therapy with tyrosine kinase inhibitors (TKIs) crizotinib.
With such an approach, we hope to inform clinical trials with biomarker development and drug discovery fueled by molecular subgrouping of this deadly group of pediatric tumors.
Nonetheless, our results are highly suggestive that low-volume ascites may be an associating clinical parameter of the "immune" molecular subgroup of HGSC.
He noted that targeted therapy, represented by tyrosine kinase inhibitors (TKIs), is replacing chemotherapy as the first-line treatment in the proper molecular subgroup of patients.
These data indicate that PLK1 may be associated with the oncogenic process in general and is not specific to a particular molecular subgroup of medulloblastoma.
Related(20)
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