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Among the 10 most cited articles, 7 reported on genomic analyses, molecular subclasses of glioblastoma and/or stem cells.
This clustering identifies two distinctive molecular subclasses of melanoma segregating aggressive metastatic tumor cell lines from less-aggressive primary tumor cell lines.
Hoshida and colleagues defined and validated three gene expression signatures of common molecular subclasses of HCC.
In addition, the accuracy of predicting the molecular subclasses of high-grade glioblastoma was as high as 87.5%.
As to the prediction of the molecular subclasses of high-grade glioblastoma, 62 DEGs were used for SVM model construction.
These findings were also observed in the different molecular subclasses of breast cancer including triple-negative tumour.
Similar(42)
Mutual exclusivity of SPOP mutation with ERG rearrangement as well as a high association with CHD1 deletion reinforces SPOP mutation as defining a distinct molecular subclass of prostate cancer.
In summary, based on the poor prognosis associated with overexpression of VDAC1 and the associated 6-gene signature, methods to target this molecular subclass of NSCLC may be effective in improve survival outcomes after surgery.
This phenotype, characterized by aberrant promoter methylation at multiple genes, identifies a distinct molecular subclass of glial tumors.
ROS1 rearrangements also define a unique molecular subclass of lung cancer that may respond to an ALK inhibitor [ 42].
One of the goals of personalized medicine is to classify patients into subpopulations that differ with respect to disease susceptibility, phenotypic or molecular subclass of a disease, or the likelihood of a positive or adverse response to a specific therapy.
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