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Calibration of the rate of molecular evolution, based on within-species genetic variation, estimated a more rapid rate of evolution than in traditional estimates.
Furthermore, the general consensus that the molecular clock is an overly simple model of molecular evolution, based on the observation that most datasets exhibit variation in substitution rates across lineages, may be in part based on error in rate estimation such as we observed in this study.
Many forms of genomic analysis rely on indirect inferences of molecular evolution based on modern observed sequences and would likely benefit from accurate knowledge of full evolutionary histories.
Thus, other than indirect effects related to population size or general pleiotropic factors [ 32, 33], there should be no functional relationship between our measure of molecular evolution, based on mitochondrial genes, and any of the phenotypic traits considered.
A GTR model with gamma distribution and invariant sites (GTR + G + I) was selected by MEGA v5.05 as the best fitting model of molecular evolution based on the Akaike Information Criterion.
Similar(54)
Although there are many uncertainties regarding the evolution of Nematoda, a molecular phylogeny, based on the use of a ribosomal subunit gene, has proposed five main clades (I-V) [ 29, 30].
Using a well-resolved molecular phylogeny based on 10 genes, we reconstruct the evolution of these characters across the family [120 steps; Consistency Index (CI): 0.41].
His population genetics work on the "neutral theory of molecular evolution" was based on his conclusions that most evolution at the molecular level is the result of random processes such as mutation and genetic drift.
After the rise of molecular genetics in the 1950s, the field of molecular evolution developed, based on protein sequences and immunological tests, and later incorporating RNA and DNA studies.
The simplest models of molecular evolution are based only on the mutation process and do not attempt to evaluate its effect on fitness.
Molecular dynamics simulations involve many calculations of protein state evolution based on molecular entropy and are computationally costly.
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