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The long term modulation of galactic cosmic rays in the heliosphere deals with the causes of the 11-year and 22-year solar cycles, while short term modulation is associated with effects of the order of a few solar rotations.

We sometimes identify just one such pattern of target interaction for a given activity or, on other occasions, find distinct sets of targets whose modulation is associated with the same function.

This modulation is associated with the risk of restenosis of an artificial vascular graft.

Phenotypic modulation is associated with specific gene expression which could be regulated by epigenetic marks, chromatin remodelling, and specific SMC transcription factor binding.

VSMCs phenotypic modulation is associated not only with change in the level of expression of differentiation proteins, but also with the reorganization of actin cytoskeleton [ 24].

This modulation is associated with complementary contributions of the basal ganglia and the hippocampus to action anticipation and the omission of action.

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Remarkably, this modulation was associated with increased miR-17/20a miR-17/20aearlevelshase, whinh would earlyin Trp53inp1 low levelS.

This lack of modulation was associated with poorer executive performance and increased WMH volumes among those older adults exhibiting extensive white matter abnormalities but was not related to elevated amyloid burden.

In animal studies that have assessed cardiac metabolic alterations, GLP-1 modulation was associated with increased myocardial glucose uptake [ 40, 41], reduced myocardial levels of lactate and pyruvate [ 42], and an increase in the relative oxidation of carbohydrate versus fat [ 41].

To further investigate whether GR modulation was associated with age, we generated a list of current known direct interacting proteins of the GR (338 interactions defined from Ingenuity Knowledge Base) and examined how the expression of these genes changed with age (ANOVA, p < 0.05).

These analyses thus revealed that several components of the insulin signalling pathway are modulated in the sg/sg phenotype, these modulations being associated with decreased blood glucose and improved insulin signalling.

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