Sentence examples for modulation in vitro from inspiring English sources

We proposed an alternative method of stem cell culture that focuses on the use of Zn++ Finger nanoparticles for stem cell expansion and transdifferentiation modulation in vitro and in in vivo spinal cord injury models.

Most of the researchers in drug development agree that the demonstration of anti-tumor efficacy in preclinical, typically animal based model of cancer is a key determinant in both, and compounds for testing should have shown target biomarker modulation in vitro and in vivo[4].

We studied the transport of nanoparticulate flurbiprofen in an in vitro BBB model, and we could convincingly demonstrate that γ-secretase modulation in vitro was significantly enhanced after BBB penetration when flurbiprofen was delivered with nanoparticles compared to flurbiprofen alone.

MiR-122 modulation in vitro and in vivo let to alterations of many genes implicated in liver metabolism, fatty acid synthesis and oxidation (Elmen et al, 2008a; Esau et al, 2006; Krutzfeldt et al, 2005).

Although in vivo human or animal intervention trials are physiologically most relevant to study both polyphenol metabolism and microbial modulation, in vitro tools have been designed to simulate intestinal conditions.

In addition to its effects on cardiomyocytes, miR-133 is also documented as a key regulator of vascular smooth muscle cell phenotypic modulation in vitro and in vivo by regulating the expression of SP-1, suggesting its potential therapeutic application for vascular diseases [ 26].

We have further analysed the consequences of preventing TCR down-modulation, in vitro and in vivo in two very different disease models; antigen-specific inflammatory arthritis and a T cell-derived lymphoma.

The PLGA core allows hydrophobic drugs to be loaded and is encapsulated in a chitosan shell that offers two functions: (i) dispersion of PLGA in an aqueous solution and (ii) modulation of in vitro drug release.

We also examined the effects of Hh pathway modulation on in vitro clonogenic growth and treated REH and RS4 11 cells with SHh-NP, 5E1, cyclopamine or IPI-926.

Summing up, artificial epigenomic modulation of in vitro cultured MSCs using the nonspecific HDAC inhibitor, designated as TSA, seems to facilitate much more the reprogramming process for epigenetically determined transcriptional activity of somatic cell-inherited nuclear genome in the NT pig embryos.

Due to the increasing therapeutic use of immunoregulatory agents and the potential effects on cellular function, we examined the modulation of in vitro beta 2-microglobulin (beta 2m) production rates by 'normal' tonsil and leukaemic B-cells in response to a number of these agents.