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Fibrin glue has been used as a carrier of many osteoinductive materials; however, its efficacy at modulating the clinical effects of BMP are not known.
Introns may also harbour SNPs that are capable of modulating the clinical penetrance of a given pathogenic mutation.
Chemoradiation induces tumor antigen-specific T-cell responses in clinical settings, which have the capability of modulating the clinical outcome of malignant diseases.
Epidemiologic and biological studies are needed to explore secondary factors modulating the clinical expression of LHON, including metabolic, lifestyle, environmental, and occupational triggers.
Research is required into secondary factors modulating the clinical expression of LHON, which could include toxic exposures, alcohol/tobacco abuse, and metabolic dysfunctions (Lachmund and Mojon 2006).
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However, other factors, including innate immunity, have also been shown to modulate the clinical outcome [8] [10], and several studies have shown that complement factors are involved [11].
So far, the use of intravitreal pharmacologic agents has not been proven to be efficacious in the prevention or treatment of PVR and most efforts have been dedicated to modulate the clinical risk factors [13], [14].
Mosaicism can also modulate the clinical course of the disease [ 6, 7].
These data demonstrate the potential of FIH-1 to modulate the clinical outcome in tumours.
Abatacept-only treatment did not modulate the clinical score compared with PBS treatment (data not shown).
Therefore, it has been speculated that the P-gp may modulate the clinical course of HIV infection independent from its role in drug transport.
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