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Due to their large coding capacity, poxviruses have developed a set of strategies to modulate their interaction with the host.
Indeed although the general 3D structure of IxACs appears to have been conserved, small changes might modulate their interaction with properdin.
The lengths of these pQ tracts can modulate their interaction strengths.
Thus, HMGB1 may act synergistically with other immunostimulatory molecules to modulate their interaction with cells and amplify their activity because of their physical association.
However, our findings suggest that MM cells themselves are being selected for clones with increased numbers of somatically mutated adhesion molecules that may modulate their interaction with bystander cells of the BM microenvironment, to promote anti-apoptotic or pro-proliferative properties, or to decrease dependency during tumor progression.
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The presence of this helical-segment in expanded variants of PABPN1 could modulate their interactions properties by changing partner specificity and/or affinity.
It has also been established that phosphorylation of some of these proteins modulate their interactions with other membrane proteins [12], [13] and, consequently, the membrane mechanical functions and membrane stability [14], [15].
Collectively, we demonstrate that C15 directly targets neutrophils, particularly once in an activated state, to modulate their interactions with inflamed endothelial cells.
In this study, we set out to explore the relationship between the nature of amino acids that constitute the 17-29 region (p53 numbering) of the TA domains in this family and their ability to fold into conformations that may modulate their interactions with MDM2; in related work the details of these interactions have been modelled [ 38].
The use of precisely designed molecular ligands to control NP surface properties provides an important toolkit for modulating their interaction with biological systems, facilitating their use in biomedicine.
The cytoskeleton controls the functional state of the integrins thus modulating their interaction with the ECM.
Related(20)
influence their interaction
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