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Therefore, we hypothesize that individual egg-laying events might be detected by the VC neurons, which in turn provide short-term negative feed back to the HSNs to modulate their activity during the active state.
Fundamental understanding of ion channel structure function mechanisms, their physiological roles, how their dysfunction leads to disease, their utility as biosensors, and development of novel molecules to modulate their activity are important and active research frontiers.
Moreover, various cellular factors can modulate their activity and mutagenic potential.
GPCRs are involved in most physiological processes, and our ability to modulate their activity is a hallmark of modern pharmacology.
A family of six insulin-like growth factor (IGF) binding-proteins (IGFBP) bind to IGF-I and IGF-II with high affinity and modulate their activity.
Given the complexity of CRL complexes, steps toward the structure-based design of small-molecule inhibitors to modulate their activity have remained elusive.
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Moving forward, we aim to acquire their dynamic structures, to better comprehend how lipids modulate their activities, and to understand how disease-associated mutations cripple the normal functions of these membrane transport proteins.
However, the molecular mechanisms that coordinate expression of these genes and modulate their activities in response to biological stimuli are less well understood.
Hybrigenics' aim is to identify new therapeutic targets, and small molecule compounds that will modulate their activities, in order to develop anticancer drugs.
The sRNAs are also known to interact with cellular proteins to modulate their activities.
Other mechanisms, like direct interaction with proteins to modulate their activities or increase stability of mRNAs, also occur.
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