Sentence examples for modulate the pulmonary from inspiring English sources

The purpose of this study was to determine whether human amnion epithelial cells (hAECs) can modulate the pulmonary developmental consequences of intrauterine inflammation in fetal sheep that are exposed to intraamniotic lipopolysaccharide (LPS) injection.

In this case, Nod1−/− and Nod2−/− mice show altered pulmonary inflammatory cell infiltration and impairment of cytokine response at different time points, suggesting that NOD1 and NOD2 distinctively modulate the pulmonary immune response after Legionella infection [ 73].

Increases in surface expression levels of CCR2 and CXCR1, respectively, might have the potential to modulate the pulmonary immune response with regard to antibacterial (CXCR1) and profibrotic (CCR2) responses [ 46, 48].

82 The chemokine receptors CXCR1 and CXCR2 play an important role in neutrophilic inflammation, and a specific CXCR1/2 haplotype cluster has been identified that is associated with lung function in CF patients and is thought to modulate the pulmonary outcome through a dysregulation of neutrophilic effector functions.

In the current study, the ability of different Francisella strains (F. tularensis subsp. tularensis SchuS4, Type B F. tularensis subsp holarctica live vaccine strain (LVS), or F.novicida) to modulate the pulmonary transcriptional response to a TLR4 agonist was investigated using an aerosol exposure mouse model.

Our results show clearly that SCTE significantly modulated the pulmonary environment of Th1- (TNF-α) and Th2-type cytokines (IL-4, IL-13, and IL-33) and chemokines (eotaxin) in BALF, and inhibited iNOS expression and MMP-9 activity in the mouse lung tissue compared with the effects in OVA-induced mice.

There is limited knowledge on how timing of drug administration or drug interactions may interfere with the repair mechanisms or modulate the expression of pulmonary toxicity.

Whether the mutations of the EGFR signalling domain referred to above also modulate the occurrence of adverse pulmonary effects of gefitinib, or interfere with repair processes of the pulmonary epithelium (Suzuki et al, 2003), is unknown at this time.

In order to determine whether the decrease in AFC and the absence of effect of β2-agonist treatment could modulate the severity of hydrostatic pulmonary oedema, ventilated control and knockout mice were submitted to acute intravascular volume expansion by saline infusion before pulmonary oedema was quantified by estimation of the volume of alveolar epithelial lining fluid (VELF) (Fig 7).

The combined results suggest that conjugation to PAMAM dendrimers and their surface modification with PEG1000 can be utilized to modulate the transport of DOX across pulmonary epithelium, and also to easily formulate the conjugates in propellant-based inhalers for pulmonary administration of anticancer therapeutics.

Despite much research, therapies to modulate the inflammatory cascade and ensuing pulmonary dysfunction that are efficacious, safe and readily manipulable have been elusive.