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The other way around, IECs are shown to modulate the microbiota through the secretion of antimicrobial peptides[16] (and reviewed in ref[15]) and by facilitating the transport of secretory IgA[17], [18].
Thus, the possibility to modulate the microbiota more selectively is highly interesting.
In contrast, some compounds present in the diet can modulate the microbiota composition, resulting in changes in the metabolic activity of intestinal bacteria [ 31].
Prebiotics are nondigestible food ingredients that are fermented in the gut and modulate the microbiota in a manner beneficial to the host [ 59– 61].
The research described ranged from large population studies, to clinical trials using dietary and other interventions to modulate the microbiota, and mechanistic studies investigating bacterial effects at the cellular and molecular level on the gut-associated immune system, the gut barrier and the gut mucosa.
Similar(55)
Saccharin directly modulates the microbiota.
It will open new perspectives for the monitoring and design of strategies for modulating the microbiota for health.
modulated the microbiota imbalance in diabetic mice (Gu et al. 2017).
Modulating the microbiota may also reduce the risk of certain diseases.
Modulating the microbiota has the potential to improve the health of the intestinal tract as well as improve the immune system and enhance the bioavailability of nutrients.
With the establishment of the gut microbiota as an environmental factor contributing to the development of cardio-metabolic disorders, interest in modulating the microbiota composition and function as a therapeutic strategy is increasing.
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