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However, whether positions relative to the closest neighbours (e.g. ahead, sided by side or behind) modulate the individual energetic cost of swimming is still unknown.

The NAT1 and NAT2 polymorphic variants may influence the metabolism of arylamine carcinogens and modulate the individual susceptibility to cancer upon exposure to environmental risk factors [ 21].

Further, genetic factors appear to modulate the individual susceptibility as the siblings of HCC individuals are more prone to develop the HCC even in the absence of HBV infection [ 7].

Polymorphisms including single nucleotide polymorphisms (SNPs) in genes involved in xenobiotic metabolism and in genes involved in oestrogen biosynthesis and metabolism might affect circulating estrogen levels and modulate the individual susceptibility to environmental carcinogens in relation to developing BC [ 5].

In order to balance their N nutritional requirements with environmental availability, plants have to modulate the individual steps of N metabolism such as up-take, reduction of NO3− to NH4+, NH4+ assimilation and N recycling.

Here, not only the cancer genes such as oncogenes, tumour suppressor genes (TSGs), mutator genes but also genes that modulate the individual susceptibility to environmental carcinogens, for example, genes involved in xenobiotic metabolism and DNA repair are involved in HNSCC development (Sturgis and Wei, 2002).

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Although the molecular and endocrine mechanisms responsible for metabolic disorders are currently unknown, present data clarify the role of social factors in modulating the individual vulnerability to weight gain and offer an important experimental tool for the investigation of the mechanisms linking stress and psychological disorders to metabolic dysfunctions.

By and large, these controls are thought to involve lineage- and developmentally-regulated changes in chromatin structure that precisely modulate the accessibility of individual Ig/TCR gene loci and/or segments, with their associated RSSs, to the unique RAG1/2 recombinase [3], [5], [10].

In addition to regulating EBV expression, there is emerging evidence that the microenvironment can also modulate the function of individual virus proteins.

Bioactive compounds that interfere with cellular biological process influence specific signaling pathways and modulate the expression of individual subsets of signature genes.

It will be of interest to subsequently determine if such interactions also occur in vivo and can modulate the cariogenicity of individual plaque samples.

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