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The polarization term was found as the most relevant to modulate the affinity of each ligand for the metal center.

Furthermore, PCL was shown not only to toughen the epoxide but also to modulate the affinity of the matrix to the fiber.

By assaying several β-carboline compounds, we define certain chemical groups that modulate the affinity of this class of compounds for inhibition of tau phosphorylation.

Similarly, syndecan-1 was found to directly interact with and modulate the affinity state of αvβ3 and αvβ5 integrins in endothelial cells to facilitate angiogenesis in vivo [52].

Subtle variations within the KIM domain as well as in adjacent non catalytic N-terminal extension of AP2Cs could be important to modulate the affinity towards different MAPKs.

Altogether, these results suggest that glucose treatment may inhibit the activity of either proteasome complex itself or modulate the affinity of AUX/IAA proteins towards proteasome complex or its intermediate component, bringing about its less degradation.

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These associations between components of different RND efflux pumps may modulate the affinities of these transporters for different substrates.

Interestingly, we observe for both F1 and F2 TnCs that the presence of Mg2+ does modulate the affinities but does not substantially alter their ratios.

The biochemical states associated with each kinesin head during stepping are coupled to mechanical transitions in an overall mechanochemical cycle: biochemical events modulate the affinities of heads to the MT and influence mechanical transitions, and mechanical states, in turn, influence the rates of biochemical processes (Block, 2007).

Sialic acid binding is shown to trigger a conformational switch that modulates the affinity for the acceptor substrate and concomitantly creates the conditions for efficient transglycosylation.

Oligosaccharides attached to Asn297 in each of the CH2 domains of monoclonal antibodies play an important role in antibody effector functions by modulating the affinity of interaction with Fc receptors displayed on cells of the innate immune system.

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