Sentence examples for regulate the affinity from inspiring English sources
ADP-ribosylation factor-like (ARL) proteins are small GTPases that undergo conformational changes upon nucleotide binding, and which regulate the affinity of ARLs for binding other proteins, lipids or membranes.
We hypothesize that these conformational transitions have biological significance in that they provide a mechanism to finely regulate the affinity of various ligands toward heparin, for example, in secretory granules undergoing exocytosis and during the mechanical interactions between cells and the extracellular matrix.
The kinetics data implied that residues 113 and 219 can regulate the affinity of the substrate and ATP molecule but do not contribute directly to the catalysis of DNA polymerization, suggesting that the ATP binding site would be distinct from the catalytic site for DNA polymerization.
Cysteine oxidation is necessary for hydratase activity, and the increased Lewis acidity of the FeIII afforded by cysteine oxidation is believed to regulate the affinity of a catalytic water molecule for the metal center.
Complex formation can be initiated either by ligand binding to the extracellular domain of integrins or by activation of intracellular signalling pathways that regulate the affinity and avidity of integrins for ligands (Luo et al, 2007).
Integrin-mediated cell adhesion, spreading and migration involve a complex interplay between the signalling pathways that regulate the affinity and avidity of integrins for extracellular matrix proteins, integrin recycling and the structure and dynamics of the actin and microtubule networks (Vicente-Manzanares et al., 2009).
The phosphorylation promotes an allosteric conformational change that is propagated to the receiver domain interface (or signaling surface), regulating the affinity of the response regulator and, in particular, of its effector domain for the downstream targets (26).
Our findings indicate that syndecan-1 regulates the affinity state of the α2β1 integrin subunit, which in turn appears to coordinate cell attachments to the matrix that are required for spreading and migration.
10.7554/eLife.02208.013 Figure 3. Phosphorylation of N-Spc110 regulates the affinity to γ-TuSC.
Since phosphorylation in the motor domain regulates the affinity of hMyo3A to actin, we examined dephosphorylation of the hMyo3A-MDIQo by retina extract, PP1c, and PP2Ac.
Thus, the OASF conformation defined by the precise intramolecular coiled-coil arrangements regulates the affinity of STIM1 ORAI1 coupling requisite for channel gating.
