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For example, miRNAs modulate differentiation of the hematopoietic lineage [17] and several ES cell-specific miRNA have been identified [18], [19] miRNAs have also been shown to regulate brain morphogenesis in zebrafish [20] and in animal development [21].

Furthermore, specific miRNAs were proposed to modulate differentiation of mouse ES cells in recent studies [21], [22], but the role of miRNAs in the regulation of stem cell growth and differentiation is poorly understood.

The type of mechanical force can modulate differentiation of connective tissue cells.

The device is also capable of applying low-frequency dynamic strain to cultured cells, however, which has been shown to modulate differentiation of mesenchymal stem cells [ 19] and myoblastic cells [ 18].

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Estrogen also directly modulates differentiation of bipotential stromal cells into the osteoblast and adipocyte lineages, causing a lineage shift toward the osteoblast, which leads to direct stimulation of bone formation [33].

Along with the reduction in TGF-β expression, the induction of Foxp3 was suppressed in IL-6-deficient mice, suggesting that in this disease model IL-6 modulates differentiation of Foxp3-positive T regulatory cells through TGF-β production.

In addition, our previous in vitro studies have demonstrated that TGF-β1 modulates differentiation of normal prostate stromal cells into myofibroblasts, a cell type that is unique to tissues undergoing fibrosis, remodeling, or reactive stroma formation in several disorders [4].

The ability of ATRA to modulate differentiation, apoptosis, and proliferation of tumor cells through inhibition of telomerase has been suggested to explain its efficacy against tumors [ 9, 10].

Mechanical cues in the microenvironment may also modulate differentiation and development of neurons [ 13].

They are also known to be able to modulate differentiation and development of Th17 cells and Treg cells [ 17, 18].

The formation of this ligand-receptor complex initiates a number of intracellular signaling cascades that modulate differentiation, survival, and activity of the osteoblasts.

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