It is possible that HIM-8 impacts H3K9me2 level by modulating activity of one or more transcriptional regulators that, in turn, modulate expression of histone-modifying enzymes.
We report the crystal structures of the add A-riboswitch and xpt G-riboswitch aptamer modules that distinguish between bound adenine and guanine with exquisite specificity and modulate expression of two different sets of genes.
To elevate levels of versican, we ectopically expressed the versican 3′-untranslated 3′-untranslatedas a competitive endogenous region modulate expression of versican.
Levels of GATA-1/GATA-2 transcription factors modulate expression of embryonic and fetal hemoglobins.
Kalyna, M. et al. Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis.
Galloway, J. N. et al. CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome.
The main strategy was to modulate expression of the genes involved in the biosynthesis of branched-chain amino acids.
As a proof-of-concept demonstration we chose to modulate expression of albumin serum protein produced by the liver.
Increasing evidence suggests that many motor systems are organized in a loosely hierarchical manner in which command neurons/systems occupy a privileged position and function to initiate and modulate expression of various types of behaviors.
For metabolic engineering it is advantageous in terms of stability, genetic regulation, and metabolic burden to modulate expression of relevant genes on the chromosome rather than relying on over-expression of the genes on multi-copy vectors.
Lastly, failure to establish a stable cyanobacterial isolate expressing native MlrA (without the N-terminus tag) via the strong cpcB560 promoter draws attention to the use of peptide tags to positively modulate expression of potentially toxic proteins.
