Sentence examples for modulate calcium release from inspiring English sources

Could mitochondrial superoxide locally modulate calcium release unit activity at rest or/and during muscle contraction?

Mutant presenilins directly modulate calcium release from ER stores [25], [26], [27].

There is strong evidence that mutated presenilin proteins can directly modulate calcium release from intracellular stores independently of Aβ production [25], [26], [27], and may also form calcium permeable channels in the endoplasmic reticulum [28].

EPA has been previously shown to incorporate into endoplasmic reticulum and sarcoplasmic reticulum membranes and thereby modulate calcium release and reuptake by these structures [ 41].

Results suggest that experimental studies treating mouse models of any of these ataxias with appropriately chosen peptides resembling the C-terminal of IP3R1 could adjust receptor sensitivity, and thereby modulate calcium release and normalize IP3 response.

Results suggest that ICpeptides may be used to modulate calcium release in various IP3R1-associated ataxias (ataxias in which IP3R1 is less abundant, e.g., SCA15/SCA16 as well as SCA1 and SCA3, or more sensitive than in wild type mice or unaffected individuals, e.g., SCA2 and SCA3 and likely SCA1).

The mechanism of action of missense point mutations in ITPR1 causing ataxia is unknown, but given the effect of IP3R in modulating calcium release it is possible that these also cause dominant negative effects, which further studies will need to elucidate.

We investigated if the Ca2+ transfer from ER to mitochondria promoted by AA might lead to fragmentation of the organelle and if Akt, modulating ER calcium release, might preserve the mitochondrial integrity, minimizing the apoptotic damage.

In taste cells, calmyrin/CIB1 has been suggested to interact with T1r2 and modulates IP3-evoked calcium release, recently (Hennigs et al. 2008).

These roles range from voltage-dependent modulation of the action potential waveform (Knock et al, 1999), to modulating responses to intracellular calcium release through BKca and SK3 (Khan et al, 1993; Pierce et al, 2008), intracellular ATP concentration through KATP (Khan et al, 1998) and uterine stretch through tandem pore channels (Tichenor et al, 2005).

The Omega class GST GSTO1-1 modulates ryanodine receptors, which are the calcium release channels in skeletal and cardiac sarcoplasmic reticulum [ 19].