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The most common modification that influences expression of genes is DNA methylation.
Glycosylation of proteins is a complex and versatile posttranslational modification that influences biological activity, protein conformation, stability, solubility, secretion, pharmacokinetics, and antigenicity (Dwek, 1998).
Ubiquitination is a particularly versatile post-translational modification that influences most, if not all, aspects of cellular biology [1].
Recent studies implicate the third UIM in casein kinase 2-dependent ataxin-3 phosphorylation [39], a modification that influences nucleocytoplasmic shuttling and intranuclear aggregation of ataxin-3.
It is an essential epigenetic modification that influences gene expression, X chromosome inactivation, and silencing of endogenous retroviruses.
DNA methylation is an important epigenetic modification that influences a variety of physiological activities of the cell, such as X chromosome inactivation, aging, temporal and spatial expression and the development of diseases [ 40].
Similar(53)
Fibrinogen represents a potential target for oxidants, and several oxidative posttranslational modifications that influence fibrinogen structure and function have been associated with disease pathogenesis.
H3.3 is a carrier of various post-translational histone modifications that influence gene transcription.
Well-established, rRNA undergoes extensive modifications that influence its processing, folding and functionality.
Previous studies have shown that estrogen receptor alpha (ERα) can cause rapid epigenetic modifications that influence the regulation of gene expression [ 49, 50].
In addition to the genes that comprise its genome, the genetic make-up of an organism also includes its epigenome a collection of chemical modifications that influence whether or not a given gene is expressed as a protein.
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