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Ubiquitination is a post-translational modification that impacts almost all cellular activities, including protein degradation, cell cycle progression, apoptosis, and autophagy.
Collectively, our results point to α-tubulin acetylation as an important modification that impacts on kinesin vesicle dynamics, actin cytoskeletal architecture and cellular function of macrophages.
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Mucin type O-glycosylation is one of the most common types of post-translational modifications that impacts stability and biological functions of many mammalian proteins.
We are seeing three significant course modifications that impact the industry.
We examined post-translational modifications that impact on microtubule stability (microtubule detyrosination and acetylation), MAP kinase signaling (ERK phosphorylation) and adhesion signals (phospho myosin light chain, phospho-FAK and tyrosine-phosphorylated proteins).
Further studies are needed to determine whether the virus re-assortants ultimately used for egg-based A(H1N1 pdm09 vaccine manufacture possessed modifications that impacted protein structure in this region, improving antigen stability.
Whether partial Tip60 loss enhances Rora-mediated gene expression by relieving ATXN1-induced Rora depletion or perhaps alters specific posttranslational modifications that impact Rora-mediated transcription remains an open question.
Each entry of Epi2miR contains the detailed information about epigenetics that can regulate the expression of miRNAs, such as epigenetic modifications that impact miRNA expression, regulators that affect epigenetic modification, genes that are proven to be directly targeted by miRNAs, tissues or conditions for detection, experimental method, species and PubMed identifier (ID).
The short-term impact of PM2.5 on cardiovascular disease admissions, and modifications of that impact, are small and difficult to measure with precision.
Histones, the main protein component of chromatin, can be subjected to a variety of post-translational modifications (PTMs) that impact on genome function by either directly affecting nucleosome stability or providing a docking site for distinct regulatory proteins.
A benefit of consultation is negotiation of project modifications that lessen impacts on species, so staff time allocated to consultation supports conservation.
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