Sentence examples for modification represents a from inspiring English sources

The use of LV/RVs for T-cell modification represents a manufacturing challenge due to the complexity of the transduction approach and the necessity of thorough quality control.

Targeted covalent modification represents a proven approach to drug discovery with the recent FDA approvals of afatanib, ibrutinib, and osimertinib agents, which were designed to undergo an irreversible hetero-Michael addition reaction with a unique cysteine residue of a specific protein.

Accumulating evidence indicates that epigenetic modification represents a molecular substrate for cellular stresses, either suppressing or promoting disease initiation [ 71].

From all that, it seems that tRNA modification represents a major enzymatic function of Elongator (Glatt and Müller, 2013).

Protein modification represents a potential target in the engineering of plants with the goal of increasing tolerance to multiple stresses.

While further evaluation of the safety and immunogenicity of this approach must be conducted, we demonstrate that Bromelain surface modification represents a valuable approach to provide synthetic particles with proteolytic activity toward tumor ECM.

The field of posttranslational protein modification represents an area of increasing research interest as new protein modifying enzymes are discovered [5], [6], [7].

Epigenetic modification represents an appealing possibility to account for low level of PPAR-γ gene expression, since methylation-mediated silencing of inhibitory transcription factors such as Fli1 or Smad7 has been implicated as a mechanism for autonomous activation of SSc fibroblasts [41],[41].

This structural modification represents an exclusive feature of partly or fully sequenced neuropteran mtDNAs and could be a peculiar genomic marker characterizing the entire order Neuroptera.

In Arabidopsis, the genes encoding the enzymes that mediate Ub modification represent a significant fraction of the genome [ 2].

Overall, these findings suggest that maternal lipid dysregulation and de novo lipogenesis have major effects on the developmental programming of offspring hepatic steatosis in the maternal obesogenic setting, with epigenetic modification representing a potential mechanism.